Table 1.
Clinical characteristics of the human samples
| Without obesity | With obesity | ||
|---|---|---|---|
| (n = 55) | (n = 76) | p value | |
| Females n (%) | 37 (67.3) | 52 (68.4) | 0.519 |
| Age (years) | 53.7 [17.4] | 48.6 [15.7] | 0.188 |
| BMI (kg/m2) | 24.9 (2.5) | 43.2 (6.8) | < 0.001 |
| Waist (cm) | 89.7 (9.6) | 126.2 (14.1) | < 0.001 |
| Fat total (%) | 32.5 (7.5) | 49.6 (5.6) | < 0.001 |
| Android fat (%) | 32.6 (10.5) | 56.5 (5.4) | < 0.001 |
| Gynoid fat mass (%) | 37.5 [15.6] | 50.6 [8.7] | < 0.001 |
| SBP (mmHg) | 124.0 (16.1) | 139.2 (19.3) | < 0.001 |
| DBP (mmHg) | 71.1 (11.0) | 78.0 (10.9) | 0.001 |
| Glucose (mg/dL) | 95.0 [13.0] | 96.0 [13.5] | 0.284 |
| HbA1c (%) | 5.5 (0.3) | 5.6 (0.3) | 0.016 |
| Cholesterol (mg/dL) | 200.0 [48.0] | 183.5 [57.0] | 0.043 |
| LDL-cholesterol (mg/dL) | 119.0 [48.0] | 112.0 [58.8] | 0.634 |
| HDL-cholesterol (mg/dL) | 63.9 (17.5) | 53.5 (12.0) | 0.005 |
| Triglycerides (mg/dL) | 79.0 [39.0] | 111.5 [75.0] | < 0.001 |
| hsCRP (mg/dL) | 0.7 [0.9] | 4.9 [7.2] | < 0.001 |
| K03695 (AU) | 1.6 × 10−1 (3.0 × 10−2) | 1.4 × 10−1 (2.4 × 10−2) | 8.0 × 10−6 |
Results are expressed as number and frequencies for categorical variables, mean and standard deviation (SD) for normal distributed continuous variables, and median and interquartile range [IQR] for non-normal distributed continuous variables. To determine differences between study groups, we used χ2 for categorical variables, unpaired Student’s t test in normal quantitative, and Mann-Whitney U test for non-normal quantitative variables. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycated hemoglobin, LDL low density lipoprotein, HDL high density lipoprotein, hsCRP high-sensitive C-reactive protein, AU arbitrary units