Table 1.
Common and specific regulated pathways in different syndromes
| The common pathways between the three syndromes (1) | The common pathways between the three syndromes (2) | Specific pathways in blood heat syndrome | Specific pathways in blood dryness syndrome | Specific pathways in blood stasis syndrome |
| Signaling pathways regulating pluripotency of stem cells | Thyroid hormone signaling pathway | Pancreatic secretion | Shigellosis | Human T-cell leukemia virus 1 infection |
| Proteoglycans in cancer | Glutamatergic synapse | Bacterial invasion of epithelial cells | Calcium signaling pathway | |
| Breast cancer | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | Endocrine and other factor-regulated calcium reabsorption | ECM-receptor interaction | |
| Transcriptional misregulation in cancer | Hedgehog signaling pathway | Th17 cell differentiation | Cell cycle | |
| Gastric cancer | Circadian entrainment | Insulin secretion | Inositol phosphate metabolism | |
| Hepatocellular carcinoma | Non-small cell lung cancer | Glucagon signaling pathway | Glycosaminoglycan biosynthesis—heparan sulfate/heparin | |
| Parathyroid hormone synthesis, secretion and action | Long-term depression | Epithelial cell signaling in Helicobacter pylori infection | Type II diabetes mellitus | |
| Wnt signaling pathway | Neurotrophin signaling pathway | Measles | ||
| Focal adhesion | Phospholipase D signaling pathway | Mitophagy—animal | ||
| EGFR tyrosine kinase inhibitor resistance | Human papillomavirus infection | Amyotrophic lateral sclerosis (ALS) | ||
| Axon guidance | Renal cell carcinoma | Hippo signaling pathway—multiple species | ||
| Rap1 signaling pathway | Endometrial cancer | Protein digestion and absorption | ||
| Ras signaling pathway | mRNA surveillance pathway | Osteoclast differentiation | ||
| MAPK signaling pathway | Cholinergic synapse | NF-kappa B signaling pathway | ||
| TGF-beta signaling pathway | Choline metabolism in cancer | Nicotine addiction | ||
| Adherens junction | Adrenergic signaling in cardiomyocytes | Synaptic vesicle cycle | ||
| Glioma | GnRH signaling pathway | Apoptosis—multiple species | ||
| Melanoma | Yersinia infection | Apoptosis | ||
| FoxO signaling pathway | Long-term potentiation | Glycosaminoglycan biosynthesis—chondroitin sulfate /dermatan sulfate | ||
| Oxytocin signaling pathway | Insulin resistance | Platinum drug resistance | ||
| Prostate cancer | Ubiquitin mediated proteolysis | Vasopressin-regulated water reabsorption | ||
| cAMP signaling pathway | Platelet activation | SNARE interactions in vesicular transport | ||
| Hippo signaling pathway | Human cytomegalovirus infection | Cocaine addiction | ||
| Cushing syndrome | AMPK signaling pathway | JAK-STAT signaling pathway | ||
| Prolactin signaling pathway | Insulin signaling pathway | RNA transport | ||
| Circadian rhythm | Relaxin signaling pathway | Other types of O-glycan biosynthesis | ||
| Dopaminergic synapse | Cellular senescence | |||
| Regulation of actin cytoskeleton | Fluid shear stress and atherosclerosis | |||
| Gap junction | TNF signaling pathway | |||
| Melanogenesis | Tight junction | |||
| cGMP-PKG signaling pathway | Chagas disease (American trypanosomiasis) | |||
| Endocrine resistance | Dilated cardiomyopathy (DCM) | |||
| Apelin signaling pathway | Longevity regulating pathway | |||
| Colorectal cancer | Pancreatic cancer | |||
| Endocytosis | Longevity regulating pathway—multiple species | |||
| Basal cell carcinoma | Sphingolipid signaling pathway | |||
| Chronic myeloid leukemia | Central carbon metabolism in cancer | |||
| PI3K-Akt signaling pathway | Aldosterone-regulated sodium reabsorption | |||
| Morphine addiction | mTOR signaling pathway | |||
| ErbB signaling pathway | Small cell lung cancer |