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. 2019 Aug 8;105(5):1369–1378. doi: 10.3324/haematol.2019.223891

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Negative correlation between increasing number of MYC copies and survival. (A) Kaplan-Meier curve comparing 2.5 year overall survival (OS) of patients with MYC-ICN ≤4 and patients with MYC-ICN >4. (B) Negative correlation between increasing number of MYC copies and survival: patients with MYC gene copies (MYC-GC) >7 and MYC-AMP showed the worse prognosis. (C) Comparison of the outcome of patients with MYC-ICN ≤4 and MYC-ICN >4 with patients with MYC translo-cation (MYC-T) or MYC-AMP: while MYC-ICN ≤4 conferred the best outcome, patients with MYC-ICN >4 had no significant difference in OS compared to MYC-T, and both these groups of patients had a better survival compared to MYC-AMP; GC: gene copies.