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. 2019 Aug 1;105(5):1274–1284. doi: 10.3324/haematol.2019.219261

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Priming analysis of bone marrow (BM) cells from Tet-off chronic myeloid leukemia (CML) and Tet-on control mice to BH3 peptides. BM cells were treated with various BH3 peptides (PUMA, 10 mM; all others, 100 mM) for 2 hours and 15 minutes. CD45⁺ or lineage-SCA-1⁺C-KIT⁺ (LSK) cells were analyzed using flow cytom-etry after the cells were stained with JC-1 and priming was calculated for each peptide. Error bars indicate standard error of the mean. BM cells were collected from mice 3-4 weeks after tetracycline cessation (Tet-off) (n=6) or from age-matched controls (Tet-on) (n=5). (A) Results of CD45⁺ cells (n=6 for Tet-off and n=5 for Tet-on). (B) Results of LSK cells (n=5 for Tet-off and n=2 for Tet-on).