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. 2020 Apr 30;138(6):671–678. doi: 10.1001/jamaophthalmol.2020.1231

Figure 1. Schematic Representation of Mendelian Randomization Analysis.

Figure 1.

Genetic variants (G) that are associated with the exposure (X, such as myopia) are used as instrumental variable. The association of genetic variants with the outcome (Y, such as retinal detachment) is only mediated through the exposure.