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. 2020 May 1;5:52. doi: 10.1038/s41392-020-0138-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Bcl-3 is overexpressed in CRC tissues and correlates with CRC patient survival. a Bcl-3 and CD133 mRNA levels in 23 matched tumors and paired normal biopsies. p = 0.0009 for Bcl-3 and p = 0.0044 for CD133 by paired t-test. b Kaplan–Meier graph shows the survival analyses of patients with colorectal cancer based on Bcl-3 expression using R2: Genomics Analysis and Visualization Platform. c Representative images of positive and negative Bcl-3 staining in CRC patients. d Kaplan–Meier graph shows the overall survival rate in CRC patients based on Bcl-3 staining using IHC assay. e Representative images of Bcl-3 and Ac-K49-β-catenin expression based on IHC of serial sections of tissue microarrays. f The expression of Bcl-3 and Ac-K49-β-catenin in CRC tissue microarrays was analyzed by Spearman rank correlation coefficient analysis; R = 0.8646; p < 0.001; n = 125. g, h Cartoon illustration of the mechanisms by which Wnt3a increases Bcl-3 protein levels. i, j Cartoon illustration of the mechanisms by which Bcl-3 regulates the Wnt/β-catenin signaling pathway