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. 2020 Apr 30;10:7316. doi: 10.1038/s41598-020-64370-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological sections of ileocecal regions of Dexamethasone-treated SCID mice infected with different C. parvum isolates. (a) C. parvum IOWA after 107 days post-infection (PI): presence of an invasive adenocarcinoma reaching the submucosa (sm) with an interruption (arrows) of the muscularis mucosae (mm) (immunohistochemical stain for alpha smooth muscle actin). Bar, 70 μm. (b) C. parvum DID after 62 days PI: presence of an adenocarcinoma invading the submucosa (hematoxylin and eosin staining). Bar, 250 μm. (c) C. parvum TUM1, after 19 days PI: high grade intraepithelial neoplasia characterized by epithelial atypia and associated with the presence of numerous parasites inside the glands (arrow) (hematoxylin and eosin staining). Bar, 12 μm. D) C. parvum CHR after 15 days PI: development of an adenocarcinoma (arrow) in the submucosa (sm) (hematoxylin and eosin staining). Bar, 30 μm.