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. 2020 Apr 30;10:7329. doi: 10.1038/s41598-020-64402-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proptosis of eyes in SKG mice is induced by increased inflammation and beige adipogenesis in the orbital fat tissue. (a) Diagram of the schedule for an innate immune stimulus by zymosan A administration starting at 8 weeks old and analyses 3 months later using SKG mice. (b–d) Images and comparisons of the area of orbital fat around the optic nerve and inflammatory cells of orbital fat around the optic nerve. The blue dashed lines demarcate orbital fat. Scale bars: 200 μm. (e,f) Images and comparison of the intensity of CD4 immunostaining in periorbital fat. The red dashed boxes are magnified in lower panels. Scale bars: 50 μm. (g,h). Images and comparison of the intensity of Ucp1 immunostaining in periorbital fat. n = 3 for each group. *P < 0.05 and **P < 0.01 versus WT by unpaired t-test.