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. 2020 Apr 30;10:7376. doi: 10.1038/s41598-020-64408-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Type I interferon (IFN-I) responsiveness does not dictate MHC-I expression or clearance of Panc02SIY100 tumors. (A) Western blot of STING and IRF3 expression in pancreatic cell lines with GAPDH loading control. (B) flow cytometric MFI of MHC-I expression of pancreatic cell lines 72 hours after stimulation with 2′3′-cGAMP or irradiation in vitro. (C) quantification of MHC-I expression of pancreatic cell lines following 72 hours IFNβ stimulation. (D) quantification of MHC-I expression of pancreatic cell lines 72 hours following irradiation at indicated doses. (E) tumor growth of mice implanted with Panc02SIY100 or Panc02SIY100-IFNAR1^ko tumors and treated as in 1A. Key: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns = not significant.