Table 3.
Combinations of quinolone phenotypes and genotypes identified in Salmonella Typhi and Salmonella Paratyphi A and B in Jiangsu, China between 2013 and 2017.
| Phenotypic profile | Genetic resistance determinant | |||
|---|---|---|---|---|
| NAL | CIP | S. Typhi (N = 94) | S. Paratyphi A (N = 25) | S. Paratyphi B (N=9) |
| R | S | WT (8) | WT (2) | WT (0) |
| qnrS1 (1) | gyrA: S83F (6) | gyrA: D87G (1) | ||
| qnrB4 (1) | gyrA: S83F; parC: T57S (7) | gyrA: D87N (1) | ||
| gyrA: S83Y (1) | gyrA: S83F; parE: I444S (1) | gyrA: S83Y (4) | ||
| gyrA: E133G (1) | parE: S498T (1) | |||
| gyrA: D87N (2) | ||||
| gyrA: D87N; gyrA: E133G (10) | ||||
| gyrA: S83F; gyrA: E133G (13) | ||||
| gyrA: S87G; gyrA: E133G (1) | ||||
| gyrA: E133G; gyrB: S426G (1) | ||||
| gyrA: D87N; aac(6′)-ib-cr4 (1) | ||||
| gyrA: S83F; gyrA: E133G; gyrA: D79G (3) | ||||
| Total | 43 | 16 | 7 | |
| R | I | WT (15) | WT (1) | WT (0) |
| gyrA: E133G (1) | gyrA: S83F (1) | qnrA1; gyrA: S83Y (1) | ||
| gyrA: D87N (1) | aac(6′)-ib-cr4 (1) | qnrS1; qnrD1 aac(6′)-ib-cr4 (1) | ||
| gyrA: S83Y (3) | ||||
| gyrA: S83F; gyrA: E133G (18) | ||||
| gyrA: D87G; gyrA: E133G (2) | ||||
| gyrA: D87N; gyrA: E133G (2) | ||||
| gyrA: S83F; gyrA: E133G; parE: I444S (4) | ||||
| gyrA: S83F; gyrA: E133G; parE: I444S; parE: Y434S (1) | ||||
| Total | 47 | 3 | 2 | |
| R | R | WT (1) | WT (1) | WT (0) |
| gyrA: D87G; gyrA: E133G (1) | gyrA: S83F (2) | |||
| gyrA: D87N; aac(6′)-ib-cr4 (1) | gyrA: S83Y (1) | |||
| gyrA: S83Y; gyrA: D87N; gyrA: E133G; parC: E84K (1) | gyrA: E133G (1) | |||
| gyrA: S83F; gyrA: D87G; parC: T57S; parC: E84K (1) | ||||
| Total | 4 | 6 | 0 | |
NAL, nalidixic acid; CIP, ciprofloxacin; R – Resistant; I – Intermediate; S – Susceptible; WT – Wild Type.