Table 2.
Statistically significant exome analysis results of reported variants associated with MS risk in this study’s case-control exome cohorts.
| Gene | SNP | Allele frequency in Kuwaiti MS cases (%) | Allele frequency in Arab healthy controls (%) | P-value |
|---|---|---|---|---|
| CD58 | rs1414273 |
G: 158 (76) A: 50 (24) |
G: 722 (87.4) A: 104 (12.6) |
0.00007 |
| EVI5 | rs11808092 |
C: 93 (63.3) A: 54 (36.7) |
C: 687 (77.9) A: 195 (22.1) |
0.00024 |
| MTHFR | rs1801131 |
T: 120 (57.1) G: 90 (42.9) |
T: 574 (65.1) G: 308 (34.9) |
0.038 |
| TNFRSF1A | rs1800693 |
T: 127 (60.5) C: 83 (39.5) |
T: 631 (75.5) C: 205 (24.5) |
0.00002 |
Variant detection frequency was variable across the two exome cohorts and computed allele frequencies reflect the proportion of alleles divided by the total number of exomes in which the variant was detected.