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Scope of the base-mediated MPV reduction of heteroaromatic ketones. Conditions: substrate (1.0 equiv, 0.10 mmol), K3PO4 (4.0 equiv), reductant (2.5 equiv), and 1,4-dioxane (1.0 M) heated at 120 °C for 16 h in a sealed vial under an atmosphere of N2. Unless otherwise noted, yields reflect the average of two isolation experiments. a Yield determined by 1H NMR analysis using hexamethylbenzene as an external standard. b Reaction heated at 130 °C for 16 h.
