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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2020 Feb 1;83(2):189–196. doi: 10.1097/QAI.0000000000002234

Figure 2:

Figure 2:

Network analysis of peripheral inflammatory mediators and pulmonary function for three clusters in PLWH and HIV-uninfected participants. The network analyses were performed using different stringency levels (0.7–0.95) as shown in panels A and B, and 0.8 refers to the stringency that was used for the analysis shown in panel C and D. In panels A and B, cluster 3 displays elevated network complexity across all stringency levels in PLWH (A) and HIV-uninfected participants (B). In panels C and D, visualizing inflammatory mediator networks reveals the presence of pathogenic Th17 cell types in PLWH (D) of cluster 3 (green arrow indicates IL-17 and GM-CSF correlation), but similar correlations were not observed in HIV-uninfected participants (C).