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. 2020 Mar 3;38(13):1409–1418. doi: 10.1200/JCO.19.02190

FIG 1.

FIG 1.

Evaluation of sensitivity of National Comprehensive Cancer Network (NCCN) criteria for pathogenic variant carriers in 3,907 women with breast cancer. (A) Percent of total pathogenic variant carriers missed by NCCN criteria in 9 breast cancer predisposition genes, 6 high-risk predisposition genes, and BRCA1 or BRCA2 (9 genes: ATM, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, and TP53; 6 genes: BRCA1, BRCA2, CDH1, PALB2, PTEN, and TP53). (B) Comparison of germline pathogenic variant frequencies between women meeting and not meeting NCCN guidelines.