1.7. Analysis.

Comparison 1: Topical azelaic acid versus other topical treatments, Outcome 7: Change in lesion counts ‐ inflamed

Change in lesion counts ‐ inflamed
Study	Time points	Azelaic acid	Topical treatments (Comparator)	P value
Aksakal 1997	Unclear	Unclear, not reported	Unclear, not reported (metronidazole)	P < 0.001 (statistical method not reported), Quote: "The results of this study showed that the AZA cream is more effective than the metronidazole cream in reducing counts of inflamed and non‐inflamed lesions of acne"
Dunlap 1997	Medium term (number of lesion)	Unclear, not reported	Unclear, not reported (3% erythromycin/5% benzoyl peroxide)	Unclear, not reported. Quote: "The result of the study demonstrated significant differences favoring 3% erythromycin/5% benzoyl peroxide over 20% azelaic acid for the following parameters: 1) reduction in inflammatory lesion..."
Gollnick 2004a	Long term: four months after start of treatment (Median of percent reduction)	70%	77% (benzoyl peroxide)	P > 0.05
Gollnick 2004b	Long term: four months after start of treatment (Median of percent reduction)	71%	63% (clindamycin)	P > 0.05
Thielitz 2015	Long term: three months after start of treatment (percent change) (n, mean ± SD)	AzA3M: n = 19, ‐32.31 ± 38.85	n = 19, ‐37.99 ± 37.63 (Adapalene)	P = 0.816