2.5. Analysis.

Comparison 2: Topical azelaic acid versus placebo, Outcome 5: Change in lesion counts ‐ non‐inflamed (percentage reduction from baseline)

Change in lesion counts ‐ non‐inflamed (percentage reduction from baseline)
Study	Azelaic acid (mean)	Placebo (mean)	P value
medium term
Cunliffe 1989	Unclear, not reported	Unclear, not reported	P < 0.027, the results demonstrated significant difference favouring azelaic acid over placebo cream.
long term
Cunliffe 1989	Long term: three months after start of treatment, unclear, not reported	Unclear, not reported	P < 0.027, the results demonstrated significant difference favouring azelaic acid over placebo cream.
long term (split‐face trials)
Hayashi 2012	Long term: 12 weeks after start of treatment, 59.0%	46.5%	Unclear, not reported