2.6. Analysis.

Comparison 2: Topical azelaic acid versus placebo, Outcome 6: Change in lesion counts (percentage reduction from baseline)

Change in lesion counts (percentage reduction from baseline)
Study	Subgroup	Topical azelaic acid	Placebo	P value
medium term
Iraji 2007	Papules number	51.2%	19.3%	0.003
Iraji 2007	Total lesion counts	60.6%	19.9%	0.002
Iraji 2007	Acne severity index	65.2%	21.3%	0.001
Iraji 2007	Comedones numbers	87.3%	23.2%	0.001
Iraji 2007	Pustules number	42.1%	17.8%	0.08
long term
Katsambas 1989a	Long term: three months after start of treatment, comedones numbers	55.6%	0%	significant difference
long term (split‐face trials)
Hayashi 2012	Long term: 12 weeks after start of treatment, total lesion counts	59.6%	45.6%	<0.001