4.11. Analysis.
Comparison 4: Topical salicylic acid versus other topical treatments, Outcome 11: Change in lesion counts ‐ various types of acne lesions (counts or %)
| Change in lesion counts ‐ various types of acne lesions (counts or %) | ||||
| Study | Time points | Salicylic acid | Topical treatments (comparator) | P value |
| parallel trials | ||||
| Babayeva 2011 | Percent reduction ‐ total lesions (long term: 12 weeks after start of treatment) | 80.2% | 85.6% (Tretinoin) | P value was not reported. Quote: "...these differences were not statistically significant..." |
| NilFroushzadeh 2009 | Percent reduction ‐ open comedones (long term: 12 weeks after start of treatment) | 64.26% | 67% (Tretinoin) | >0.05 |
| NilFroushzadeh 2009 | Percent reduction ‐ papule (long term: 12 weeks after start of treatment) | 84.5% | 71.67% (Tretinoin) | 0.031 |
| NilFroushzadeh 2009 | Percent reduction ‐ total lesions (long term: 12 weeks after start of treatment) | 77.91% | 72.20% (Tretinoin) | 0.039 |
| NilFroushzadeh 2009 | Percent reduction ‐ pustules (long term: 12 weeks after start of treatment) | 90% | 76.19% (Tretinoin) | >0.05 |
| NilFroushzadeh 2009 | Percent reduction ‐ closed comedones (long term: 12 weeks after start of treatment) | 87.05% | 60.94% (Tretinoin) | 0.011 |
| split‐face trials | ||||
| Kessler 2008 | Percent reduction ‐ total lesion(treatment duration of 10 weeks, measured at one month post‐treatment) | 47% | 43% (30% glycolic acid peel) | > 0.05 |
| cross‐over trials | ||||
| Shalita 1989 | number of lesions post intervention ‐ comedo counts (short term) | 10.9 | 14.9 (10% benzoyl peroxide wash) | No difference |