13.6. Analysis.

Comparison 13: Topical alpha‐hydroxy acid versus other topical treatments, Outcome 6: Change in lesion counts ‐ total (counts or %)

Change in lesion counts ‐ total (counts or %)
Study	Time points	Alpha‐hydroxy acid, mean ± SD or %	Topical treatments, mean ± SD or %	P vaule
parallel trials
Hunt 1992	Short term ‐ lesion counts reduction	gluconolactone 14% in solution, not reported	benzoyl peroxide 5% lotion, not reported	No difference
Hunt 1992	Long term: 12 weeks after start of treatment ‐ lesion counts reduction	gluconolactone 14% in solution, not reported	benzoyl peroxide 5% lotion, not reported	No difference
Hunt 1992	Medium term ‐ lesion counts reduction	gluconolactone 14% in solution, not reported	benzoyl peroxide 5% lotion, not reported	No difference
split‐face trials
Kessler 2008	Percent reduction ‐ total lesion(treatment duration of 10 weeks, measured at one month post‐treatment)	30% glycolic acid peel, 43%	30% salicylic acid peel, 47%	> 0.05