Change in lesion counts ‐ non‐inflamed (counts or %)
Study	Subgroup	Salicylic acid	Placebo	P value
Eady 1996	Number reduction ‐ short, medium and long term (12 weeks after start of treatment)	Unclear, not reported	Unclear, not reported	no difference; 0.047; < 0.001
Shalita 1981	Percent reduction ‐ open comedones (long term: 12 weeks after start of treatment)	39%	28%	not reported, but the author stated the difference is significant.
Shalita 1981	Percent reduction ‐ closed comedones (long term: 12 weeks after start of treatment)	21%	21%	No difference