Change in lesion counts ‐ inflamed counts (counts or %)
Study	Subgroup	Nicotinamide (mean, sd)	Topical treatments (mean, sd)	P value
short term
Shalita 1995	Percent reduction ‐ inflamed	Unclear	Unclear	0.06
medium term
Shalita 1995	Percent reduction ‐ inflamed	59.5±41.2	42.7±41.3	0.17
Weltert 2004	Number of lesions post intervention ‐ inflamed lesion counts	4±8	5±5	not report, the author did not state whether the difference is statistical significant.