CTRI/2018/06/014615.

Study name	Comparative efficacy of glycolic acid 35% vs salicylic acid 20% peel in acne vulgaris
Methods	Randomised, parallel group trial
Participants	Inclusion criteria of the trial Participants of active facial acne of grade 1 and 2, not requiring systemic therapy Participants of either sex, age more than 18 years Mild acne (grade 1): comedones < 30; predominance of comedones papules < 10; No scarring Moderate acne (grade 2): comedones any number; predominance of papules > 10; nodules < 3; scarring +/‐ Severe acne (grade 3): comedones any number; many nodules; papules any number; nodules/cysts > 3; scarring + Exclusion criteria of the trial Participants with active facial dermatitis or infection, polycystic ovarian disease, endocrine abnormality and tendency for keloid and hypertrophic scars Participants who have taken oral retinoids in the last 6 months Pregnant and lactating participants Participants with known hypersensitivity to glycolic acid or salicylic acid Age minimum: not provided Age maximum: not provided Gender: not provided
Interventions	Group 1 participants will be given 35% glycolic acid (GA) peels which will be applied for a period of 3 minutes or until appearance of erythema, whichever is earlier. The applied GA shall be neutralised with 10% sodium bicarbonate solution and distilled water soaked gauze pads. Group 2 participants will be given 20% salicylic acid (SA) peels which will be applied until there is uniform light white coat of pseudo frost. After pseudo frosting, the peel will be washed away with distilled water. Total estimated number of participants enrolled: 60
Outcomes	Primary outcome of the trial To study the comparative efficacy of 35% glycolic acid versus 20% salicylic acid peel in acne vulgaris. Timepoint: baseline (0 week) ‐ 1st peel; 2nd week ‐ 2nd peel; 4th week ‐ 3rd peel; 6th week ‐ 4th peel; 8th week ‐ follow‐up Secondary outcomes of the trial To study the adverse effects, if any, associated with these peeling agents. (persistent erythema, burning, pain, pruritus, transient hyperpigmentation, hypopigmentation, oedema, acneiform eruption, allergic reaction, scarring, folliculitis, desquamation, post‐peel cracking, any other). Timepoint: baseline (0 week) ‐ 1st peel; 2nd week ‐ 2nd peel; 4th week ‐ 3rd peel; 6th week ‐ 4th peel; 8th week ‐ follow‐up Definition: not provided Visits: see above
Starting date	July 2018
Contact information	Name: Dr Gurvinder Pal Thami Address: Department of Dermatology, Government Medical College and Hospital, Sector 32, Chandigarh 160030 Chandigarh, CHANDIGARH India Telephone: not provided Email: thamigp@gmail.com Affiliation: Government Medical College and Hospital, Chandigarh Name: Dr Purva Pande Address: Department Of Dermatology, Government Medical College and Hospital, Sector 32, Chandigarh 160030 Chandigarh, India Telephone: not provided Email: thamigp@gmail.com Affiliation: Government Medical College and Hospital, Chandigarh Apps.who.int‐ID: CTRI/2018/06/014615
Notes	Not yet recruiting