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. 2020 May;62(5):657–667. doi: 10.1165/rcmb.2019-0158OC

Figure 1.

Figure 1.

(A) Adenoviral (Ad)-transforming growth factor (TGF) β–exposed cystic fibrosis (CF) mice have greater increases in lung resistance at methacholine doses up to 100 mg/ml compared with PBS-exposed CF mice. *P < 0.05 versus CF mice treated with PBS by two-way ANOVA with Tukey’s post hoc test. (B) Ad-TGFβ–exposed CF mice demonstrate a delayed methacholine (MTCH)-induced peak change in resistance and delayed resolution of resistance alterations compared with non-CF mice. Resistance was measured during each of 12 single-frequency forced oscillation technique perturbations, taken approximately every 12 seconds after each nebulized treatment. *P < 0.05 by two-way ANOVA. (C) The areas under the curve of the resistance changes induced by 25 and 100 mg/ml of methacholine are higher in CF than non-CF TGFβ-exposed mice. *P < 0.05 by two-tailed t test. Data are presented as mean ± SD.