Table 1.
MicroRNA Expression in Extracellular Vesicles Isolated from Human Mesenchymal Stem Cells and Lung Fibroblasts
miRNA | MSCEV 2207 | MSCEV 2216 | MSCEV 718 | FLEV 001 | FLEV 0853 | FLEV 8197 | P Value by t Test | Fold Increase |
---|---|---|---|---|---|---|---|---|
hsa-miR-196b-5p | 0.368 | 1.502 | 0.346 | 11.602 | 12.051 | 8.409 | 0.001 | 988 |
hsa-miR-615-3p | −0.843 | 0.306 | 3.949 | 11.602 | 6.559 | 8.409 | 0.020 | 210 |
hsa-miR-452-5p | 1.136 | 1.944 | 2.221 | 5.192 | 4.956 | 8.409 | 0.019 | 21 |
hsa-miR-224-5p | −2.162 | −1.563 | −0.795 | 0.052 | 2.969 | 1.392 | 0.033 | 7.8 |
hsa-let-7e-5p | −2.708 | −0.932 | −2.139 | 0.091 | 0.313 | −0.597 | 0.034 | 3.6 |
hsa-miR-127-5p | −0.150 | −0.499 | 0.009 | 2.100 | 1.345 | 1.414 | 0.003 | 3.6 |
hsa-miR-23a-3p | −4.576 | −5.383 | −5.156 | −6.130 | −6.183 | −5.849 | 0.018 | 0.50 |
hsa-miR-744-5p | −1.189 | −0.344 | −0.113 | −1.895 | −1.484 | −2.064 | 0.027 | 0.42 |
hsa-miR-33b-5p | 8.980 | 8.537 | 9.046 | 5.984 | 5.064 | 1.149 | 0.033 | 0.04 |
Definition of abbreviations: FLEV = lung fibroblast extracellular vesicle; miR = microRNA; MSCEV = mesenchymal stem cell extracellular vesicle.
Normalized number of cycles for select miRs in MSCEV and FLEV.