TABLE 2.

Strongest network of inflammatory markers contributing to Combinatory Immune Signature that were common between HIV-uninfected (HIV-) women and virally suppressed women with HIV (HIV+VS).

Combinatory immune signature	HIV-serostatus
	HIV- (n = 56)	HIV+VS (n = 49)
1	Immune activation & vascular dysfunction	Immune activation & vascular dysfunction
	Beta-2 microglobulin, Clusterin, Cystatin C, sCD14, sVEGFR2	Beta-2 microglobulin, Clusterin, Cystatin C, sCD14, sVEGFR2
2	T Cell-dependent antiviral response	T Cell-dependent antiviral response
	TRAIL/CD253, IL-10, FGF-2, Fractalkine/CX3CL1, SDF-1a + b/CXCL12, ITAC/CXCL11	TRAIL/CD253, IL-10, BCA-1/CXCL13, 6CKINE/CCL21
3	Neuroinflammatory signaling	Neuroinflammatory signaling
	Fractalkine/CX3CL1, FGF-2, serum amyloid A, CRP	TRAIL/CD253, serum amyloid A, CRP, IL-10, Adiponectin

Markers in italics were negatively associated with the profile; otherwise, the markers were positively associated with the profile. Our analyses focused on how the interrelated networks of inflammatory mediators cooperated together. As such, the same categorical description could be assigned for Combinatory Immune Signatures, despite having non-identical composition of individual immune markers.