TABLE 5.
Descriptive statistics for immune signature loadings and cognitive function for the subset of participants with neuropsychological (NP) test performance data available.
| Variable | HIV− (n = 49) M (SD) | HIV+VS (n = 34) M (SD) | |
| Immune signature loadings | |||
| 1 | Immune activation & vascular dysfunction | −22.5(0.4) | −22.7(0.4) |
| 2 | T Cell-dependent antiviral response | 0.07 (1.0) | 0.02 (1.0) |
| 3 | Neuroinflammatory signaling | 0.09 (0.8) | 0.07 (0.7) |
| 4HIV– | Depressive/Psychiatric disorder infammatory response | 0.02 (0.82) | − |
| 5HIV– | Anti-inflammatory microglial activity | −0.05(0.7) | − |
| 6HIV– | Cytokine mediated inflammatory response | −0.04(0.4) | − |
| 7HIV– | T Cell exhaustion | −0.02(0.4) | − |
| 4HIV+VS | Myeloid, T Cell, and Endothelial Cell communication | − | −0.02(0.7) |
| 5HIV+VS | Microglial chemokine-mediated T Cell recruitment to brain | − | 0.06 (0.6) |
| 6HIV+VS | Leukocyte recruitment to brain | − | 0.00 (0.5) |
| 7HIV+VS | Oxidative stress | − | 0.04 (0.5) |
| Neuropsychological test performance | |||
| Global NP function | 3.5 (2.1) | 3.2 (1.7) | |
| Learning | 48.4 (8.9) | 50.7 (9.9) | |
| Memory | 48.4 (9.9) | 51.6 (9.7) | |
| Attention/WM | 50.2 (9.5) | 48.1 (11.2) | |
| Executive Function | 48.9 (9.8) | 48.4 (9.3) | |
| Speed | 49.6 (10.5) | 50.5 (9.9) | |
| Fluency | 48.5 (9.3) | 50.5 (9.6) | |
| Motor | 47.6 (12.9) | 50.2 (8.9) | |
M, mean; SD, standard deviation; WM, working memory; global NP function, higher values equal poorer cognition.