Table 4.
ViroPanel Concordance
| Previous virus test result | ViroPanel—primary virus detected | Concordant samples, n | Total virus-positive sample count |
|---|---|---|---|
| HHV-8 (+) | HHV-8 | 8/8 | 8 |
| HBV (+) | HBV | 6/6 | 6 |
| HPV6 (+) | HPV6 | 1/1 | 1 |
| HPV11 (+) | HPV11 | 1/1 | 1 |
| HPV45 (+) | HPV16∗ | 1/1∗ | 1 |
| HPV16 (+) | HPV16 | 13/13 | 13 |
| HPV16 (+) | HPV18† | 1/1† | 1 |
| HPV18 (+) | HPV18 | 4/4 | 4 |
| HPV33 (+) | HPV33 | 6/6 | 6 |
| HPV35 (+) | HPV35 | 4/4 | 4 |
| HPV53 (+) | HPV53 | 2/2 | 2 |
| HPV56 (+) | HPV56 | 1/1 | 1 |
| HPV61 (+) | HPV61 | 1/1 | 1 |
| HPV82 (+) | HPV82 | 1/1 | 1 |
| MCPyV (+) | MCPyV | 6/6 | 6 |
| HPV (−) | HPV16 (1 sample) | 6/7 | 1 |
| MCPyV (−) | None | 3/3 | 0 |
| None | MCPyV | NA | 43 |
| Total | 65/66 | 100 |
Number of concordant samples is listed by virus type along with the total number of controls concordant and total number of samples determined to be positive for virus infection. ViroPanel found evidence to support positive virus infection for 100 samples. Of 58 samples with no previous virus testing, ViroPanel showed 43 to be positively infected for MCPyV. Sample 28 previously tested negative for HPV was found by ViroPanel to be positive for HPV16 (listed as discordant). Of 66 virus controls, 65 were concordant.
HBV, hepatitis B virus; HHV-8, human herpesvirus 8; HPV, human papillomavirus; MCPyV, Merkel cell polyomavirus.
Sample 16 was previously reported to be HPV45 positive but found by ViroPanel to be HPV16 positive (see Discrepant Sample Review and Sensitivity and Specificity).
Sample 123 was previously assigned as positive for HPV16 on the basis of p16 expression. ViroPanel found this sample to be co-infected with HPV16, HPV18, and HPV33 (see Co-Infection Status), with HPV18 representing the primary infecting virus.