Figure 7.
(A–C) Effects of IGF-1 (insulin-like growth factor-1) treatment on RV hypertrophy (A) and lung function (B and C) in infant rats after antenatal endotoxin (ETX) injection in experimental chorioamnionitis rhIGF-1 (recombinant human IGF-1)/BP3 (binding peptide 3) treatment causes dose-related improvement in RV hypertrophy, total respiratory system resistance (B), and compliance (C). Box plots represent median, interquartile range, and minimum–maximum data points. Animal numbers per study group: control rats = 20; ETX = 19; rhIGF-1/BP3 0.02 mg/kg = 10; 0.2 mg/kg = 18; 2 mg/kg = 19; and 20 mg/kg = 8. LV+S = left ventricle plus septum; RV = right ventricle.