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Overview of the study illustrating the genome-wide analysis, intersection with previous findings, and replication of the results. COPD = chronic obstructive pulmonary disease; COPDGene = Genetic Epidemiology of COPD; DGE = differential gene expression; DNAm = DNA methylation; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; EWAS = epigenome-wide association study.
