Survival curves for PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit δ) CpG sites in COPDGene (Genetic Epidemiology of COPD). (A) For the site cg03971555, the subjects alive at enrollment for each bin: n = 160 (red), n = 159 (green), n = 159 (blue), and n = 159 (black). Thirty samples have missing DNAm data (total n = 637). The subjects alive at last time point: n = 121 (red), n = 136 (green), n = 143 (blue), and n = 144 (black). (B) For the site cg12033075, the subjects alive at enrollment for each bin: n = 167 (red), n = 167 (green), n = 166 (blue), and n = 167 (black). The subjects alive at last time point: n = 124 (red), n = 144 (green), n = 148 (blue), and n = 150 (black). Marks show times with data censoring. The time unit is days. COPD = chronic obstructive pulmonary disease; DNAm = DNA methylation.