Table 3.

Associations between DNAm at the Replicated Sites from the Genome-Wide Cox Proportional Hazard Analysis^* and COPD Status, Baseline Lung Function, Emphysema Phenotypes, and Survival Status

CpG Site	Gene Symbol	Survival Status† (PValue)	Survival Status (Adjusted Mean Difference in % DNAm‡)	COPD Status§ (P Value)	COPD Status (Adjusted Mean Difference in % DNAm||)	FEV1% Predicted¶ (P Value)	Percent Emphysema** (P Value)
cg08007647	C1orf146	0.0066	−0.2	0.76	−0.02	0.7	0.97
cg19828537	FAM178B	0.00062	−0.6	0.084	−0.2	0.078	0.017
cg02618319	USP2	0.012	−0.2	0.36	−0.05	0.42	0.59
cg04226365	CDC5L	0.00054	0.2	0.22	0.05	0.2	0.75
cg24542441	SEPT10	0.014	0.3	0.91	0.01	0.83	0.84
cg03971555	PIK3CD	2.31 × 10−5	5.0	0.036	2.0	0.023	0.036
cg12033075	PIK3CD	1.52 × 10−5	4.7	0.00069	2.9	0.00029	0.00031

Definition of abbreviations: COPD = chronic obstructive pulmonary disease; DNAm = DNA methylation; PIK3CD = phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit δ.

Survival status is binary: alive or deceased.

^*See Table 2.

^†Model 1: DNAm ∼ survival status + COPD + age + sex + pack-years + smoking + batch.

^‡Negative DNAm difference corresponds to reduced levels (hypomethylation) with mortality; positive DNAm difference corresponds to increased levels (hypermethylation) with mortality.

^§Model 2: DNAm ∼ COPD + age + sex + pack-years + smoking + batch.

^||Negative DNAm difference corresponds to hypomethylation with COPD, reduced FEV1 and increased emphysema; positive DNAm difference corresponds to hypermethylation with COPD, reduced FEV1 and increased emphysema.

^¶Model 3: DNAm ∼ FEV1% predicted + age + sex + pack-years + smoking + batch.

^**Model 4: DNAm ∼ Percent emphysema + age + sex + body mass index + pack-years + smoking + batch.