Figure 1.

Fourteen-day mycobactericidal activity of intravenous meropenem (Mero) 6 g once daily over 6 hours versus 2 g every 8 hours, compared with that of ertapenem (Erta) 1 g once daily intramuscularly and isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE) dosed once daily according to standard weight bands. All Mero- and Erta-containing groups received amoxicillin plus clavulanic acid orally twice daily. The darker blue lines represent the estimated daily on-treatment change in colony-forming units [log₁₀cfu], adjusted for baseline cfu, age, body mass index, sex, and study. The lighter blue shadows are the associated 95% confidence bands. The solid squares represent the time point of sputum collection. We used a single joint linear mixed-effects model, taking into account the correlation between observations from each participant.