Table IV.
Predictors of 14-day mortality following infection with Klebsiella pneumoniae carbapenemase-producing organisms (KPCO)
| Variable | Alive at 14 days (N=77) |
Died by 14 days (N=20) |
Univariate |
Multi-variate |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N/median | %/IQR | N/median | %/IQR | Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | |
| Age, per year | 57 | 46–65 | 57 | 43–66 | 0.99 | (0.96–1.03) | 0.64 | 1.00 | (0.97–1.03) | 0.84 |
| Female | 29 | 38% | 4 | 20% | 0.44 | (0.16–1.21) | 0.11 | 0.47 | (0.15–1.42) | 0.18 |
| Active therapy | 67 | 87% | 11 | 55% | 0.23 | (0.08–0.62) | 0.004 | 0.32 | (0.09–1.10) | 0.07 |
| Source control | 43 | 56% | 1 | 5% | 0.05 | (0.01–0.39) | 0.004 | 0.07 | (0.01–0.44) | 0.005 |
| Number of previous KPCO infections, per infection | 0 | 0–1 | 0 | 0–1 | 0.99 | (0.64–1.53) | 0.96 | 0.76 | (0.47–1.24) | 0.27 |
| Infection with intrinsically colistin-resistant KPCO | 13 | 17% | 9 | 45% | 3.05 | (1.39–6.69) | 0.005 | 1.97 | (0.83–4.68) | 0.12 |
| Charlson score, per point increase | 2 | 0–5 | 4 | 0.5–6 | 1.10 | (0.98–1.24) | 0.10 | 0.98 | (0.84–1.15) | 0.81 |
| Infection focus, intra-abdominal (baseline) | #N/A | #N/A | #N/A | #N/A | 1.00 | 1.00 | ||||
| Bacteraemia | 18 | 23% | 2 | 10% | 0.48 | (0.10–2.22) | 0.35 | 1.12 | (0.30–4.21) | 0.86 |
| Pneumonia | 18 | 23% | 7 | 35% | 2.37 | (0.49–11.47) | 0.29 | 0.74 | (0.23–2.43) | 0.62 |
| Other | 1 | 1% | 1 | 5% | 1.54 | (0.55–4.34) | 0.41 | 2.12 | (0.54–8.30) | 0.28 |
CI, confidence interval.
Note: not including 46 patients with KPCO urinary tract infections, none of whom died within 14 days.