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. 2020 Apr 24;11:511. doi: 10.3389/fphar.2020.00511

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Copyright © 2020 Udawatte, Kang, Wang, Arumugam and Seneviratne

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxicity of each drug on HK-2 cells determined by quantitative CellTiter-Glo® of ATP Luminescent Cell Viability Assay. CC₅₀ of Logarithm curves (A) SM21, (B) SM21 Analogue, (C) Amphotericin B, and (D) Voriconazole. The graphs were plotted based on logarithm of drug dosage and the CC₅₀ was calculated by probit regression method using Prism 8. SM21 and its analogue showed lesser cytotoxicity and potency to induce proximal tubular damage in HK-2 compared to AmB (4.82, 5.36, and 1.5 μM; respectively). HK-2, immortalized human kidney proximal tubule epithelial cells.