Figure 4.

Change in kidney and body weights of male Sprague Dawley rats, (A) Mean body weight change in each group at 15 mg/kg/day BW over treatment period of 5 days. There were no clinical signs of toxicity at any time point and decrease in group mean body weights were observed in SM21 and analogue treatment groups in parallel with vehicle and negative control (Voriconazole) from day 1 to day 5. Whereas in Amphotericin B group, two of nine rats were removed on day 3 due to overt sign of toxicity at 15 mg/kg and slight decrease in body weight gain (–8%) compared with vehicle was observed in the rest of rats from day 1 to day 5. (B) Correlation between kidney weight and body weight of rats in each group on day 5. Kidney weights data were subjected to the linear regression and correlation was established with corresponding body weights using Prism's correlation matrix. There is poor or no correlation was found of kidney weights with body weights in the present study (P > 0.05).