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. 2020 Apr 24;11:511. doi: 10.3389/fphar.2020.00511

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Copyright © 2020 Udawatte, Kang, Wang, Arumugam and Seneviratne

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hematoxylin and eosin staining of kidney sections of Sprague Dawley rats treated with 15 mg/kg/day BW of Vehicle, SM21 and Amphotericin B groups after treatment for 5 days. Six micrographs taken from the cortex of kidney in Vehicle (A, D), Amphotericin B (B, E), SM21 (C, F) groups. Control groups [Vehicle and voriconazole (not shown)] showed no abnormality. SM21 treatment group (SM21 and its analogue) had similar findings of the control groups along with mild tubular necrosis. Among tubular necrosis in Amphotericin B group, loss of the brush border of tubuli (pink arrow in Figure E), mild tubular cell vacuolation (black arrow in Figure E), intratubular cast formation (red arrow in Figure B), disengagement of cells into lumen of tubuli (yellow arrow in Figure E) were significantly observed. SD, Sprague Dawley.