Table 1.

SCr and BUN were significantly increased at day 5 observed in AmB treated group whereas change of alterations of tested drug SM21 and its analogue treated groups fall in the range of negative control (voriconazole) and vehicle treated groups, but the magnitude of these alterations were much lower than that of almost all of the urinary kidney injury biomarkers (2-fold, 1.4-fold increases over vehicle-treated rats, respectively).

Group	Dose(mg/kg)	n	SCr(mg/dl)	BUN(mg/dl)
Vehicle	15	9	0.697 ± 0.1399	4.386 ± 0.917
Voriconazole	15	9	0.717 ± 0.154	4.140 ± 0.790
AmB	15	7	**1.044 ±0.119	*6.35 ± 0.591
SM21	15	9	0.801 ± 0.075	4.87 ± 1.308
SM21 Analogue	15	9	0.801 ± 0.069	4.96 ± 1.529

Significantly difference deemed as *P < 0.05; **P< 0.01. SCr, Serum creatinine; BUN, Blood urea nitrogen; AmB, Amphotericin B.