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. 2020 Apr 24;11:703. doi: 10.3389/fimmu.2020.00703

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Copyright © 2020 Callahan, Kammala, Syed, Yang, Occhiuto, Nellutla, Chumanevich, Oskeritzian, Das and Subramanian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Osthole attenuates MRGPRX2-mediated degranulation in human skin mast cells. (A–C) Human skin-derived mast cells were pre-treated with osthole (OS, 72 and 144 μM) and exposed to (A) compound 48/80 (C48/80, 100 ng/ml), (B) substance P (SP, 300 nM) or (C) LL-37 (3 μM). Graphs show degranulation of mast cells as estimated by β-hexosaminidase release in supernatants. Data shown are from 4 different human donors with each symbol representing a single donor. Statistical significance was determined by paired Student’s t-test *p < 0.05 and **p < 0.01.