Table 3.
The pathologic abnormalities of kidney in 26 cases of deceased patients with COVID-19
| ID | LM |
EM |
IF |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tubule interstitium |
Glomeruli |
|||||||||||
| ATI | Multiple foci of bacteria | Pigmented casts | Arteriosclerosis | Segmental fibrin thrombus | FSGS | Coronavirus-like particles | Dense deposits | Subendothelial lucent expansion | IgG | IgA | SARS-CoV NP | |
| 1 | Severe | N | N | Mild to moderate | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 2 | Moderate | N | N | Mild | N | N | Y | N | N | N/A | N/A | N/A |
| 3 | Mild to moderate | N | Y | Mild | N | N | Y | N | Y | N/A | N/A | N/A |
| 4 | Severe | N | N | Severe | N | Y | Y | N | Y | N/A | N/A | N/A |
| 5 | Mild | N | N | Mild | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 6 | Mild to moderate | N | Y | Mild | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 7 | Severe | N | N | Mild to moderate | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 8 | Moderate | N | N | Severe | Focal | Y | N/A | N/A | N/A | N/A | N/A | N/A |
| 9 | Moderate | N | Y | Moderate | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 10 | Moderate | N | N | Moderate to severe | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 11 | Moderate to severe | N | N | Moderate to severe | Focal | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 12 | Moderate to severe | N | N | Moderate | N | N | Y | N | Y | N/A | N/A | N/A |
| 13 | Mild to moderate | N | N | Mild | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 14 | Severe | Multiple focal | N | Moderate | Diffuse | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 15 | Mild to moderate | N | N | Moderate to severe | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 16 | Severe | Multiple focal | N | Moderate to severe | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 17 | Moderate | N | N | Moderate | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 18 | Moderate | N | N | Mild | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 19 | Mild | N | N | Moderate to severe | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
| 20 | Moderate to severe | N | N | Moderate | N | N | Y | N | N | N | N | N |
| 21 | Mild | N | N | Moderate to severe | N | N | N | Y | Y | Y | N | N |
| 22 | Moderate | N | N | Mild to moderate | N | N | Y | N | N | N | N | Y |
| 23 | Moderate | N | N | Moderate | N | N | N | N | N | N | N | Y |
| 24 | Mild | N | N | Mild | N | N | N/A | N/A | N/A | N | N | N |
| 25 | Moderate to severe | N | N | Moderate to severe | N | N | Y | Y | Y | N | Y | Y |
| 26 | Mild to moderate | N | N | Mild | N | N | N/A | N/A | N/A | N/A | N/A | N/A |
ATI, acute tubular injury; COVID-19, coronavirus disease 2019; EM, electron microscopy; FSGS, focal segmental glomerulosclerosis; ID, identification number; IF, immunofluorescent (stain); LM, light microscopy; N, not detected; N/A, not available; NP, nucleoprotein; SARS-CoV, severe acute respirator syndrome coronavirus; Y, detected.