Table 1.

Top cited RCC cell lines.

Histologic and genetic characteristics, including ccA and ccB sub-classification, and 3p deletion status as defined by Sinha et al., are outlined¹⁰. VHL and other known significantly mutated genes, determined by TCGA, are defined by CCLE and CCLP databases^58,66,67,142.

Cell line	Classification	Sub classification10	Histological features	3p status10	VHL status66,67	CCLE mutations66, 67
		(Sinha et al., 2017)		(Sinha et al., 2017)	(Barretina et al., 2012)	(Barretina et al., 2012)
786-O	ccRCC	ccB	Poor differentiation with sarcomatoid features10	Deleted	Null	PTEN, TP53,
			(Sinha et al., 2017)			TSC2, MLL3
A-498	ccRCC	ccB	Compact nests of tumor cells with clear cytoplasm10	Deleted	Null	MLL3, SETD2
			(Sinha et al., 2017)
ACHN	pRCC	Unknown	Poor differentiation with sarcomatoid features10	Deleted	Wildtype	PBRM1, NF2
			(Sinha et al., 2017)
CAKI-1	ccRCC	ccB	Poor differentiation71	Not Deleted	Wildtype	MET, MLL3,
			(Korhonen et al., 1994)			SETD2
RCC-4	ccRCC	Unknown	Unknown	Deleted	Null	NA
A-704	ccRCC	ccA	Not tumorigenic in immunocompromised mice73	Deleted	Null	MLL3, TP53,
			(Giard et al., 1973)			PBRM1, SETD2
SN12C	Unknown	Unknown	Clear cell combined with granular morphology74	Not Deleted	Wildtype	TP53, BAP1,
			(Sanchez et al., 1994)			NF2
CAKI-2	ccRCC	ccB	Well differentiated clear cell71	Deleted	Wildtype	PBRM1
			(Korhonen et al., 1994)
769-P	ccRCC	ccA	Unknown	Deleted	Null	BAP1, TSC2
TK-10	Unknown	Unknown	Unknown	Deleted	Wildtype	PIK3CA, TP53
UMRC-2	ccRCC	ccA	Unknown	Deleted	Null	NA
OS-RC-2	ccRCC	ccB	Unknown	Deleted	Null	PTEN, TP53,
						PBRM1
CAL-54	pRCC	Unknown	Well differentiated with papillary structures75	Deleted	Wildtype	FH, MLL3
			(Gioanni et al., 1996)