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. 2020 Apr 24;11:523. doi: 10.3389/fphar.2020.00523

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Copyright © 2020 Xu, Lv, Deng, Liu, Gong, Shi and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICS II protected against OGD/R-induced primary hippocampal neurons injury. (A) After 8 d cultured, NSE was labeled on hippocampal neurons, further observed by fluorescence microscope. (B) Neurons were induced by OGD 1.5 h then reperfusion 24 h, different concentrations of ICS II (12.5, 25, or 50 μM) were administrated during the reperfusion, and the cell viability was determined by MTT assay. (C) LDH release from hippocampal neurons was measured using an LDH release assay. (D) The protective effects of ICS II on OGD/R-induced morphological alternation. Data are presented as means ± SD (n = 3). ^**P < 0.01 versus control group; ^#P < 0.05, ^##P < 0.01 versus OGD/R group.