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. 2020 Apr 24;11:523. doi: 10.3389/fphar.2020.00523

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Copyright © 2020 Xu, Lv, Deng, Liu, Gong, Shi and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICS II up-regulated the expressions of BDNF, p-TrkB, TrkB, and p-CREB after OGD/R insult. (A) Representative Western blot images of BDNF, p-TrkB, and TrkB. (B) Quantitation of BDNF. (C) Quantitation of p-TrkB. (D) Quantitation of TrkB. (E) Representative Western blot images of p-CREB and CREB. (F) Quantitation of p-CREB/CREB. TrkB-specific inhibitor ANA-12 abolished the beneficial effects of ICS II. (G) Cell viability tested by MTT assay. (H) LDH release was detected using an LDH release assay kit. Data are presented as means ± SD (n = 3). ^**P < 0.01 versus control group; ^#P < 0.05, ^##P < 0.01 versus OGD/R group, ^&P < 0.01 versus OGD/R+ ICS II 50 group.