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. 2020 Apr 24;11:523. doi: 10.3389/fphar.2020.00523

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Copyright © 2020 Xu, Lv, Deng, Liu, Gong, Shi and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICS II binds and inhibits PDE5. (A) PDE5 protein expression was detected by ELISA kit. (B) PDE5 activity was detected by PDE5 activity kit. (C) Visual result of binding surface between ICS II and PDE5. (D) Visual result of binding sites between ICS II and PDE5. (E). Visual result of binding surface between SIL and PDE5. (F) Visual result of binding sites between SIL and PDE5. (G) 2D interaction sides between ICS II and PDE5. (H) 2D interaction sides between SIL and PDE5. Data are presented as means ± SD (n = 3). ^*P < 0.05, ^**P < 0.01 versus control group; ^#P < 0.05, ^##P < 0.01 versus OGD/R group.