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. 2020 Apr 24;11:505. doi: 10.3389/fphar.2020.00505

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Copyright © 2020 Yuan, Qiao, Yang, Yu, Sun, Qian, Zhang, Meng, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPB and C_u characteristics of VRC in plasma from patients and blank plasma spiked with drugs in different C_t. There was a trend of positive relationship between C_t and PPB (A, R=0.291), C_t and C_u (B, R=0.724) in plasma from patients. Patients with a higher C_t in group IV had a significantly higher PPB (C, group I vs. group IV, p=0.012; group II vs. group IV, p < 0.01; group III vs. group IV, p<0.01). Blank plasmas spiked with VRC in vitro were divided into four groups according to drug concentration (D). There was a significant lower PPB of 400 ng/ml VRC than 16,000 ng/ml VRC (p=0.01), or 25,000 ng/ml VRC (p<0.01); 1,500 ng/ml VRC had a significantly lower PPB than 25,000 ng/ml (p=0.012).