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. 2020 Apr 24;11:505. doi: 10.3389/fphar.2020.00505

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Copyright © 2020 Yuan, Qiao, Yang, Yu, Sun, Qian, Zhang, Meng, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPBs of plasma protein solutions spiked with VRC in vitro were grouped according to total drug concentration. ALB binding rate of samples with a higher concentration of VRC (C_t=25,000 ng/ml) was significantly higher in different protein groups (A, 30 g/L, p=0.047; 50 g/L, p=0.015). Plasma protein mixtures spiked with a higher concentration of VRC (C_t=25,000 ng/ml) had a significantly higher PPB than the lower concentration group (C_t=400 ng/ml) in both two different protein groups (D, 40.01 g/L, p<0.01; 81 g/L, p<0.01). There was no difference in AAG or GLB binding rate between different drug concentration groups (B, C).