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. 2020 Apr 24;11:505. doi: 10.3389/fphar.2020.00505

Figure 5.

Figure 5

Unbound drug concentrations of plasma protein solutions spiked with VRC in vitro were grouped according to protein concentration. L or H represented in vitro samples in lower or higher Cp, respectively. MIX represents the plasma protein mixtures in vitro. In a lower Ct (A, 400 ng/ml), Cu of in vitro samples with a lower plasma protein concentration was significantly higher than samples with a higher plasma protein concentration (40.01 vs. 81 g/L, p<0.01). In a higher Ct (B, 25,000 ng/ml), Cu of in vitro samples with a lower AAG concentration was significantly higher than samples with higher AAG concentration (0.01 vs. 1 g/L, p<0.01), and Cu of in vitro samples with a lower GLB concentration (10 g/L) was significantly higher than samples with a higher GLB concentration (30 g/L, p<0.01).