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. 2020 Apr 24;11:505. doi: 10.3389/fphar.2020.00505

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Copyright © 2020 Yuan, Qiao, Yang, Yu, Sun, Qian, Zhang, Meng, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between AST or ALT level and drug concentration, respectively. There was no significant difference between patients with AST in normal value and those with abnormal AST (shown in A, B) in C_min. The total C_max of VRC in patients with AST in normal value were significantly lower than those with abnormal AST value (p<0.01, C). The unbound C_max of VRC in patients with normal AST was lower than those with abnormal AST value (p<0.01, D). ALT values showed no significant influence on either C_t or C_u in minimum or maximum concentration (E–H).