Figure 4.

Spine morphing in APP_SDL mice is differentially affected in hippocampal subfields of the two sexes. Trajectories representing the fractions of different spine classes from CA1 and CA3 pyramidal neurons in APP_SDL transgenic and control B6 mice of different ages as determined by algorithm-based classification. Please note that the age of mice had been displayed in weeks to represent it as scaled time intervals. Statistical data were assessed using a generalized linear model from six to seven mice per condition (see the total number of dendritic segments used for each condition in Supplementary Table S1). The p-value of the genotype, age effects, and their interaction are shown below the graphs. Distribution of individual data points are presented in Supplementary Figures S3, S4.