Figure 1. A) Estimated marginal means for fine motor dexterity (summed time of four trials in 9HPT) and cognitive functioning (DRS total score) after covariating for age (mean, 74.2) and education (mean, 4.6). Significant group differences in fine motor dexterity were found between controls and MDaMC (p = 0.009), controls and AD (p < 0.001), and aMCI and AD (p = 0.004). For cognitive measures, all comparisons were significant (p < 0.001), following the pattern controls > aMCI > MDaMCI > AD. B) Effect sizes (partial eta-squared) from the main effects of fine motor dexterity and cognitive functioning in self-care, instrumental-domestic, and instrumental-complex ADLs (AD). We found specific contributions of cognitive functioning to instrumental ADLs and fine motor dexterity for self-care ADLs. 9HPT = Nine-Hole Peg Test; AD = Alzheimer’s disease dementia; ADLs = activities of daily living; aMCI = single-domain amnestic mild cognitive impairment; DRS = Dementia Rating Scale; MDaMC = multiple-domain amnestic mild cognitive impairment.