eTable 5. Multivariate analysis of the factors associated with death at the weaning center, weaning failure and the need for long-term NIV.

	Wald‘s chi-square	P	Odds ratio [95% CI]
In-hospital mortality: n = 8339; chi² (8) = 306.04; p < 0.0001
Age at admission (absolute value in years)	78.7350	0.0000	11.07 [6.51; 18.82]
Tidal volume(absolute value in ml)	13.7646	0.0002	0.34 [0.19; 0.60]
Interstitial lung disease	11.9879	0.0005	1.56 [1.21; 2.00]
Critical illness polyneuropathy	30.7911	0.0000	0.65 [0.56; 0.76]
Obesity (ever)	20.3116	0.0000	0.71 [0.61; 0.82]
Coronary heart disease	16.6748	0.0000	1.32 [1.15; 1.50)
Renal failure	59.0255	0.0000	1.68 [1.47; 1.92]
Oncological/hematological disease (ever)	14.3753	0.0002	1.38 [1.17; 1.63]
Weaning failure: n = 6339; chi² (12) = 391.95; p < 0.0001
Reason: postoperative ARI	11.7699	0.0006	0.72 [0.59; 0.87]
Reason: acute exacerbation of COPD	12.0867	0.0005	1.33 [1.13; 1.56]
Reason: neuromuscular (acute on chronic)	21.7264	0.0000	2.98 [1.88; 4.73]
Age at admission (absolute value in years)	21.6143	0.0000	2.96 [1.87; 4.69]
Body mass index (absolute value in kg/m2)	21.3490	0.0000	0.38 [0.26; 0.58]
Duration of invasive ventilation before transfer to weaning center (days)	65.9623	0.0000	4.73 [3.25; 6.89]
ECOG performance status	45.8064	0.0000	2.17 [1.73; 2.72]
Pre-existing long-term non-invasive ventilation	49.5668	0.0000	1.98 [1.64; 2.40]
COPD	6.0590	0.0138	1.20 [1.04; 1.40]
Restrictive thoracic disease	15.9438	0.0001	1.57 [1.26; 1.95]
Neuromuscular disease	21.4888	0.0000	1.87 [1.43; 2.43]
Arterial hypertension	5.3314	0.0210	1.29 [1.04; 1.60]
Initiation of NIV: n = 7207; chi² (17) = 1357.5; p < 0.0001
Reason: postoperative ARI	8.9055	0.0028	0.77 [0.64; 0.91]
Reason: obesity hypoventilation (acute on chronic)	19.3283	0.0000	2.78 [1.76; 4.39]
Reason: acute exacerbation of COPD	64.6147	0.0000	1.84 [1.59; 2.14]
Reason: neuromuscular (acute on chronic)	23.4927	0.0000	3.64 [2.16; 6.14]
Reason: ALI/ARDS	4.0324	0.0446	0.71 [0.51; 0.99]
Reason: Trauma/burns	7.6559	0.0057	0.36 [0.17; 0.74]
Reason: Others	7.2008	0.0073	0.76 [0.62; 0.93]
Age at admission (absolute value in years)	27.9406	0.0000	0.32 [0.21; 0.49]
Body mass index (absolute value in kg/m2)	36.1524	0.0000	3.68 [2.41; 5.63]
Pre-existing long-term non-invasive ventilation	321.2916	0.0000	6.28 [5.13; 7.67]
COPD	108.4588	0.0000	2.02 [1.77; 2.30]
Restrictive thoracic disease	24.6761	0.0000	1.82 [1.44; 2.30]
Obesity (ever)	11.5340	0.0007	1.30 [1.12; 1.52]
Coronary heart disease	4.3049	0.0380	0.88 [0.77; 0.99]
Arterial hypertension	39.6919	0.0000	1.87 [1.54; 2.28]
Delirium	22.2039	0.0000	0.70 [0.60; 0.81]
Others (ever)	12.1258	0.0005	0.81 [0.72; 0.91]

Significant parameters are only shown in the final model.

OR values <1 are given in black, OR values > 1 in red.

For continuous parameters, the OR values refer to the maximal range of the parameter from minimum to maximum value; no categorization was undertaken.

ALI, Acute lung injury; ARDS, acute respiratory distress syndrome; ARI, acute respiratory insufficiency; CI, confidence interval; COPD, chronic obstructive pulmonary disease, ECOG, Eastern Cooperative Oncology Group; NIV, non-invasive ventilation; OR, odds ratio